Dissertations at Graduate School GUIDE

This list shows the dissertations of GUIDE PhD-students from 2003 up to now. By clicking the header of a column, the content of that column will be disposed. The title is the link to additional information about the dissertation. Part of this information is provided by the University Library.

Number of dissertations: 404

Date Name Title Inst.
2010 Dijkman, Ulrike Inhibition of Kynurenine aminotransferase : a potential new drug target for the treatment of schizophrenia
2010 Jellema, Laurens-Jan Cornelis New strategies for (biological) particle handling and separation in microfluidic devices
2010 Schorr, Susanne Gabriele Drug safety in patients with psychotic disorders
2010 Cate, Bram ten Targeted apoptosis induction in hemato-oncology
2010 Fehrmann, Rudolf Stephan Nicolaas High dimensional data analysis for new insight in ovarian cancer phenotypes
2010 Gangaram-Panday, Shanti Tireshma Embryogenesis and neogenesis of the endocrine pancreas : the role of c-met, c-kit and nestin positive cells
2010 Geel, Tessa Marieke Pompe disease : towards gene correction using targeted nucleases
2010 Heijden, Gert-Jan van der Metabolic effects of exercise in adolescent obesity
2010 Laan, Hans Paul van der Optimising CT guided radiotherapy for breast cancer
2010 L'Abée, Carianne Infant growth. Practices of objectivity in cerebral imaging 17th century-present
2010 Liem, Eryn Tamara Development of overweight in adolescence : genes, growth & mood
2010 Loon, Rosa Laura Elisabeth van Paediatric pulmonary hypertension : epidemiology, characterisation and treatment
2010 Rienstra, Heleen Chronic tissue remodeling in renal transplantation : studies on cell origin, proteoglycans, and response to intervention
2010 Rikhof, Bart New insights in tailored treatment of gastrointestinal stromal tumours
2010 Veeger, Nicolaas Johannes Gerardus Maria Individual approach towards optimal oral anticoagulation
2010 Vliet, Michael Johannes van Mucosal barrier injury : new parameters and the role of microbiota
2010 Voorham, Jaco Assessing cardiometabolic treatment quality in general practice
2010 Nguyen, Thi Le Thu Langmuir-Blodgett films of unidirectionally aligned α-helical diblock copolypeptides
2010 Parikh, Kausal Bharat Kinome profiling : methods and applications
2010 Dekkers, Bart Gerrit Jan Major role of the extracellular matrix in airway smooth muscle phenotype plasticity : implications for chronic asthma
2010 Staniek, Agata Agnieszka Endophytes as alternative paclitaxel sources : chemistry and genetics of Taxomyces andreanae and the endophytic flora of Wollemia nobilis
2010 Pennarun, Bodvaël Improving the response to molecular targeting of the TRAIL death receptors in colon cancer cells
2010 Haadsma, Maaike Laura Female reproductive ageing : the clinical relation between oocyte quantity and oocyte quality
2010 Laksmana, Fesia Lestari Functional encapsulation of small particles : quantification and control of the morphology of the coating layers : quantification and control of the morphology of the coating layers
2010 Meijer, Jiska Marianne Sjogren's syndrome: treatment and treatment evaluation
2010 Jong, Wilhelmina Hiltje Agnes de Neuroendocrine biomarkers in clinical chemistry : method development and clinical validation of automated LC-MS/MS methods
2010 Sibbald, M.J.J.B. The Staphylococcus aureus secretome
2010 Hoeksma, Marieke PKU: food for thougt
2010 Bottema, Renske Willemijn Bernadette Complex pathways to atopy development. Genes and environment
2010 Herrema, Hillechien Jeltje Interplay between glucose, fatty acid and bile salt metabolism in mouse models of fatty liver
2010 Liu, Gaifen Genetic and environmental effects on obesity and insulin resistance : findings in youth
2010 Dijk, Taeke Henderikus van Computational analysis of carbohydrate metabolism : stable isotop techniques in small laboratory animals
2010 Koolman, Anna Hendrike The role of the endocannabinoid system in the regulation of energy balance
2010 Lukovac, Sabina Essential fatty acid deficiency and the small intestine
2010 Han, Lina Signal transduction pathways in acute myeloid leukemia
2010 Bolling, Maria Caroline Epidermolysis bullosa simplex : new insights in desmosomal cardiocutaneous syndromes
2010 Nijstad, Niels Novel insights into HDL function and metabolism
2010 Pereboom, Ilona Tapke Annie Blood platelets in liver transplantation : clinical studies on the function of blood platelets and primary hemostasis during and after liver transplantation
2009 Abello, Nicolas Jean-Robert Chemical labeling for the analysis of proteins, peptides and metabolites by mass spectrometry
2009 Al Hadithy, Asmar Faris Yassin Pharmacogenetics of antipsychotic-induced Parkinsonism and tardive dyskinesia: a focus on African-Caribbeans and Slavonic Caucasians
2009 Boersma, Cornelis Health economics of cardiovascular & renal disease prevention : from clinical trials to real-life settings
2009 Boersma, Christiaan Infrared emission features: probing the interstellar PAH population and circumstellar environment of Herbig Ae/Be stars
2009 Dijkstra, Arend Gerrit Models for nonlinear optical spectra of coupled oscillators
2009 Khan, Ansar Ali Regulation of metabolizing enzymes and transporters for drugs and bile salts in human and rat intestine and liver : a study with precision-cut slices
2009 Krzeslak, Joanna Kamila Pseudomonas as a microbial enzyme factory : the source of industrially potent enzymes and the host for heterologous enzyme production
2009 Boerma, Evert-Jan Gijsbert Molecular definition of Burkitt Lymphoma
2009 Borensztajn, Keren Sarah Action and Function of coagulation FXa on cellular signaling
2009 Broers, Carolina Johanna Maria De nurse practitioner: verpleegkundig specialist tussen care en cure
2009 Brouwer, Jan Leendert Pouwel Clinical implications of deficiencies of protein S, protein C or antithrombin
2009 Buck, Sandra Optimization of cardiac resynchronization therapy in atrial fibrillation and sinus rhythm
2009 Damman, Kevin Cardiorenal interaction in heart failure
2009 Doormaal, Jasperien Elisabeth van Medication errors and adverse drug events in hospitalised patients; methodological issues and computerised intervention
2009 Folkeringa, Nienke Pregnancy-related thrombosis and fetal loss in women with thrombophilia
2009 Graeff, Pauline de Molecular markers in epithelial ovarian cancer : paving the way to innovative therapies
2009 Ham, Tjakko Jakob van Caenorhabditis elegans models for protein misfolding diseases
2009 Jansen , Nathalie Chantal Anja José Cognitive functioning of children treated for acute lymphoblastic leukaemia with chemotherapy-only
2009 Jansen, Theodorus Water-in-oil emulsions as adjuvant for inactivated vaccines
2009 Jong, Johan de The GALM effect study: changes in physical activity, health and fitness of sedentary and underactive older adults aged 55-65
2009 Karliczek, Anne Anastomotic leakage : risk assessment in gastrointestinal surgery
2009 Knibbe, Mare Els 'Not a matter of choice' : ethical perspectives on decision making about living parental liver donation
2009 Koudstaal, Lyan Giela The impact of cerebral injury in donation and transplantation : a central role of the intestine
2009 Kouwen, Roelof Hendrik Matthijs Protein secretion and disulfide bond handling in Bacillus subtilis
2009 Kroon, Hidde Maarten Isolated limb infusion
2009 Lazzeri, Elena Nuclear Medicine imaging of vertebral infections: role of radiolabelled biotin
2009 Maduro, John Henry TRAILs towards improved cervical cancer treatment
2009 Meijering, Bernadet Dagmar Marielle Ultrasound and microbubble targeted delivery : exploring the mechanism and its therapeutic potential
2009 Mulder, Jaap Towards treatment of cholestatic liver disease in children via interference with transcriptional regulation of hepatic transport systems
2009 Pelinck, Maria Josephina Modified natural cycle IVF : feasibility and results
2009 Persoon, Adrienne Cornelia Maria New insights in the follow-up of differentiated thyroid carcinoma
2009 Piers, Lieuw Hendrik Computed tomography for the evaluation of the aortic valve and coronary arteries
2009 Pultrum, Bareld Bastiaan Staging and treatment related problems of loco-regional disease in patients with esophageal cancer
2009 Ree, Rutger M van Chronic low-grade inflammation in renal transplantation
2009 Rook, Mieneke Living kidney donor safety : insights & outcome
2009 Sanders, Johannes Stephanus Franciscus Disease-activity in ANCA-associated vasculitis
2009 Schaar, Hilde Margot van der Cell entry mechanisms of dengue virus
2009 Schreurs, Marijke Regulatory enzymes of mitochondrial B-oxidation as targets for treatment of the metabolic syndrome
2009 Siedlinski, Mateusz Iwo Genetic and environmental determinants of lung function in the general population
2009 Smelt, Maaike Joyce The role of CMV in the pathology and etiology of islet graft failure
2009 Straten, Esther Maria Elisabeth van Programming of lipid metabolism
2009 Tan, Lu Ping MiRNAs and their target genes in B cell lymphomas
2009 Verhagen, Anton Albert Eduard End-of-life decisions in Dutch neonatal intensive care units
2009 Chen, Min Pathogenetic and clinical aspects of ANCA-associated vasculitis
2009 Vroom, Fokaline Drug use in pregnancy : exploring the field of Disease Modifying Antirheumatic Drugs in pregnancy
2009 Holvast, Albert Influenza vaccination in systemic autoimmune diseases
2009 Kok, Klaartje Expression, action and function of phosphoinositide 3-kinase p110delta
2009 Ploeg, René van der The minimal Tat translocase
2009 Prins, Jelle Tjitse Burnout among Dutch medical residents
2009 Hagen, Franziska Maria vom Experimental models of retinal angiogenesis : the effect of angiopoietin-2 and TNFα modulation
2009 Rafat, Neysan The endothelium in sepsis: inflammatory response and progenitor cell involvement
2009 Tanke, Marit Aline Christine Serotonin, cortisol, and stress-related psychopathology : from bench to bed
2009 Reijmerink, Naomi Elizabeth A Search for missing pieces of the puzzle; the development of asthma and atopy
2009 Qi, Liqiang MicroRNA expression patterns in precursor lesions and (hereditary) breast cancer
2009 Melenhorst, Wynand Bernhard Willem Henderik The biology of ADAMs in renal disease
2009 Oosterveer, Maaike Helene Control of metabolic flux by nutrient sensors
2009 Ulu, Nadir Vascular function in chronic end-organ damage : pharmacological characterization of vasomotor function in systemic vasculature
2009 Pol, Hendrik Jan Computer based instructional support during physics problem solving : a case for student control
2009 Martens, Henk Allard Genetic and prognostic factors in lupus
2009 Vleuten, Pieter Adriaan van der Left ventricular function after STEMI : developments in diagnostics and cell therapy
2009 Gameren, Ingrid Irene van Diagnostic and therapeutic modalitis in systemic amyloidosis
2009 Leffers, Ninke Targeted immunotherapy for ovarian cancer
2008 Amorij, Jean-Pierre The development of stable influenza vaccine powder formulations for new needle-free dosage forms
2008 Boer, Johannes Wietse de cis-Dihydroxylation and Epoxidation of Alkenes by Manganese Catalysts - Selectivity, Reactivity and Mechanism
2008 Hulst, Marinus van Health economics of blood transfusion safety
2008 Klein, Theo Profiling of soluble and membrane-bound metalloproteinases: A targetted proteomics approach
2008 Lemke, Andreas New formulation approaches for the leishmanicidal drug Miltefosine and for the olyene antibiotic Amphotericin B.
2008 Reinders, Mattheus Karsien Practice research in the field of gout - clinical pharmacology of antihyperuricemic drugs
2008 Swertz, Morris A Dynamic software infrastructures for the life sciences
2008 Abdulahad, Wayel Habib T-cell mediated immunity in Wegener's granulomatosis
2008 Been, Lukas Berend Imaging proliferation with [18F]FLT-PET : therapy evaluation studies
2008 Bergh, Alphonsus Cornelis Maria van den Radiation therapy in pituitary adenomas
2008 Blaauwbroek, Ria Caring for adult survivors of childhood cancer : the role of the general practitioner
2008 Blokzijl, Johannes Functional regulation of transport proteins in gastrointestinal and liver disease
2008 Boelens, Mirjam Catharina Molecular genetic studies in epithelial cells of lung cancer and COPD patients
2008 Booman, Marije The role of immunoediting in lymphomas of immune-privileged sites
2008 Borggreve, Susanna Etje The role of CETP and HDL metabolism in cardiac disease
2008 Bos, Evelien Henriette Evaluation of a preventive intervention among hospital workers to reduce physical workload
2008 Bosveld, Floris Physiological implications of impaired de novo Coenzyme A Biosynthesis in Drosophila melanogaster
2008 Brandsma, Corry Anke The inflammatory response in COPD : in mice and men
2008 Brantsma, Auke Hedman Course and consequeces of high urinary albumin excretion
2008 Buijs, Ciska Long-term side effects of adjuvant breast cancer treatment
2008 Buis, Carlijn Ineke Molecular and biochemical mechanisms of bile duct injury after liver transplantation
2008 Burlage, Fred Ronald The role of pilocarpine in the reduction of radiation induced damage to the salivary glands
2008 Crijns, Anne Petra Gerarda Prognostic microarray in ovarian cancer : toward patient-tailored therapy
2008 Didraga, Mihaela Alina Analytical approaches towards structural characterization of human lung decorin
2008 Diemen, Cleo Catharina van Genetics of lung function decline and COPD development
2008 Dikkers, Riksta New developments in non-invasive coronary imaging
2008 Duiker, Evelien Wilma Targeting the extrinsic apoptosis pathway in ovarian cancer
2008 Duiverman, Marieke Leontine Severe Chronic Obstructive Pulmonary Disease : assessment of respiratory muscle activity and the benefits of noninvasive ventilation
2008 Dunning, Sandra Resistance of activated stellate cells to cell death in liver fibrosis : mechanisms and targets for intervention
2008 Geluk, Christiane Anneliese Coronary risk stratification : from PREVEND to the prevention of coronary events
2008 Gibcus, Johan Harmen Characterization of the 11q13.3 amplicon in head and neck squamous cell carcinoma
2008 Groen, Jaap Michiel A phantom study on cardiac parameters as measured by imaging modalities
2008 Groenewegen, Hendrik Cornelis Therapeutic and mechanistic explorations of in-stent restenosis in the rat aortic stenting model
2008 Guichelaar, Maureen Maike Johanna Bone disease before and after liver transplantation : clinical studies in cholestatic liver disease
2008 Hageman, Jurre The human HSP70/HSP40 chaperone family : a study on its capacity to combat proteotoxic stress
2008 Hamming, Inge Novel insights in the pathogenesis of renal interstitial damage during ACE inhibition : a role for ACE2 and the (pro)renin-receptor?
2008 Hartog, Jasper Willem Louis Advanced glycation end-products in cardiac and renal failure
2008 Hettema, Martha Elisabeth Micro- and macrovascular abnormalities in systemic sclerosis
2008 Hoenders, Caroline Simone Martine Microorganisms and inflammation in the long term "aseptic" loosening process of total hip implants : face the interface
2008 Jong, Wouter Karst de Thoracic tumors: prognostic and thearapeutic improvements
2008 Jongen, Vincentius Hubertus Willibrordus Maria Hormonal and molecular aspects of endometrioid endometrial cancer
2008 Kelder, Wendy Lymph node staging in colon cancer
2008 Koopmans, Klaas Pieter Metabolic PET tracers for neuroendocrine tumors
2008 Lambeck, Annechien Jansine Almtje Novel immunotherapeutic strategies for gynaecologic malignancies
2008 Lambers Heerspink, Hiddo Jan Perspectives on randomized clinical trials : the case for albuminuria
2008 Leeuw, Karina de Premature atherosclerosis in systemic autoimmune diseases
2008 Libourel, Eduard Josephus Thrombophilia, from laboratory tests to clinical impact of single and multiple defects
2008 Liesker, Jeroen Johannes Wilhelmus COPD : a multifaceted disease
2008 Lutgers, H.L. Skin autofluorescence in diabetes mellitus
2008 Neels, Olivier Christiaan Tracer development for detection and characterization of neuroendocrine tumors with PET
2008 Nieboer, Peter High-dose chemotherapy : studies on supportive care, quality of life and late effects of treatment
2008 Oterdoom, Leendert Harmen Insulin resistance, renal dysfunction and cardiovascular disease, studies in a high and a low risk population
2008 Ou, Jianghua Functional analysis and carrier detection of mismatch repair gene mutations
2008 Pellicoro, Antonella Hepatic peroxisome function in health and disease
2008 Polak, Wojciech Grzegorz Technical aspects of liver transplantation
2008 Popkov, Alexander Development of new precursors for asymmetric preparation of α-[11C]methyl amino acids for PET
2008 Riezebos-Brilman, Annelies Development of a therapeutic vaccination strategy against cervical neoplasia
2008 Smit, Jaap Jan Johannes Platelets and white blood cells in acute coronary syndromes
2008 Song, Hui Cold preservation injury in organ transplantation: beneficial effects of dopamine and carbon monoxide releasing molecules
2008 Stassen, Patricia Maria ANCA-associated vasculitis. Triggers and treatment
2008 Svenson, Karen Louise The development and implementation of a high-throughput phenotyping platform for identification of a new mouse models of cardiovascular disease
2008 Tan, Eng Shiong Advanced clinical approaches in complex cardiovascular disease : invasive options at the crossroad of ischemia, heart failure, and arrhythmias
2008 Timmeren, Mirjan Miranda van The proximal tubular cell, a key player in renal damage
2008 Tintelen, Johannes Peter van Inherited cardiomyopathies
2008 Tuinman, Marrit Annika Surviving testicular cancer : relationship aspects
2008 Versluis, Mieke Adenosine and its receptors : translational studies in asthma and COPD
2008 Visser, Folkert Willem Monitoring extra cellular fluid volume during renal function measurement
2008 Vlieg-Boerstra, Berber Standardization, validation and outcome of double-blind, placebo-controlled food challenges in children
2008 Vogelzang, Mathijs Computer assisted decision support in acutely ill patients. Application in glucose management and quantification of myocardial reperfusion
2008 Vogt, Liffert Strategies to optimize renoprotective therapy in proteinuric renal patients
2008 Vrenken, Titia Eveline Mechanisms and prevention of hepatocyte cell death
2008 Bosma, Renate Jolanda Role of renal hemodynamics in obesity associated renal risk
2007 Boersma, Ykelien Lolkje Evolution of enantioselectivity: selection of improved hydrolase variants
2007 Govorukhina, Natalia I. Biomarker discovery for cervical cancer
2007 Kemperman, Ramses Franciscus Jacobus Nutrition and biomarkers in psychiatry : research on micronutrient deficiencies in schizophrenia, the role of the intestine in the hyperserotonemia of autism, and a method for non-hypothesis driven discovery of biomarkers in urine
2007 Kerkhof, Esther Gesina van de Drug metabolism in human and rat intestine: an in vitro approach
2007 Schaafsma, Dedmer Central role of Rho-kinase in the pathophysiology of allergic asthma
2007 Temming, Kai New ways in RGD-peptide mediated drug targeting to angiogenic endothelium: On the nature of drugs, linkers, and carriers.
2007 Tuin, Annemarie Detoxification of LPS by alkaline phosphatase : application of a new concept in sepsis and inflammatory bowel disease
2007 Albada, Mirjam Ellen van Pulmonary arterial hypertension : cardiovascular effects of pharmacological intervention
2007 Bakker, Nicolaas Arjen Presentation and early detection of posttransplant lymphoproliferative disorder after solid organ transplantation
2007 Bathoorn, Derk COPD exacerbations, inflammation and treatment
2007 Borst, Martin Hendrik de Protein kinase signaling: Intracellular messengers as potential targets for intervention in renal disease
2007 Bos, Hendrik Therapy resistance to the antiproteinuric and renoprotective efficacy of ACE-inhibition
2007 Brinkman, Jacoline Willijanne Albuminuria as a laboratory risk marker : Methods evaluated
2007 Broekema, Martine Bone marrow-derived cells in renal repair
2007 Brugman, S The influence of dietary and bacterial antigens on the development of type 1 diabetes in the Bio Breeding Diabetes Prone rat
2007 Cohen, Judith Parameters of small airway function and inflammation
2007 Dasselaar, Judith Johanna Relative blood volume measurements during hemodialysis: merits and limitations
2007 Deen, Margaretha van der Role of multidrug resistance-associated protein 1 in airway epithelium
2007 Derks , Terry Gerardus Johannes MCAD deficiency : clinical and laboratory studies
2007 Diepstra, Arjan Classical Hodgkin lymphoma: population based studies on HLA and EBV
2007 Donker, Rogier Bertrand Endothelial and trophoblast (dys)function in preeclampsia
2007 Doting, Meintje Hylkje Edwina Sentinel lymph node biopsy in breast cancer and melanoma
2007 Drenthen, Willem Pregnancy and delivery in women with congenital heart disease
2007 Engelen, Mirjam Johanna Antonia Critical appraisal of patterns of care in ovarian cancer
2007 Foster, Juliet Michelle Development and validation of the inhaled corticosteroid questionnaire : a model for the measurement of patient-perceived side effects by self-report
2007 Francken, Anne Brecht Primary and metastatic melanoma : aspects of follow-up and staging
2007 Gallagher, Alice Classical Hodgkin lymphoma: investigation of the disease pathogenesis with a focus on viral involvement
2007 Greving, Jacoba Petronella Trends in cardiovascular drug prescribing in Dutch general practice : role of patient and physician related characteristics
2007 Grigoryan, Larissa Self-medication with antibiotics in Europe and its determinants
2007 Hart, Nils Arnaud ’t Improving liver preservation : new strategies in liver procurement and preservation
2007 Hemels, Martin Eric Willem Rhythm control strategies for symptomatic atrial fibrillation
2007 Heuvel, Marinus Christianus van den Bile ductules as the habitat of bipotential progenitor cells: regeneration in human liver disease
2007 Hovenga, Sjoerd Clinical and biological aspects of Multiple Myeloma
2007 Jonge, Jørgen Martin de Reconstituted viral envelopes as delivery vehicles for nucleic acids
2007 Klunder, Lammert Sorting and trafficking of proteins in oligodendrocytes during myelin membrane biogenesis
2007 Kooi, Elisabeth Maria Wiepkje; Schokker, Siebrigje Preschool children with recurrent respiratory symptoms
2007 Kuldo, Joanna Melania Pharmacological strategies to interfere with proinflammatory signal transduction in endothelial cells
2007 Lely, Anna Titia Towards an integrated approach on RAAS-blockade
2007 Lesman-Leegte, Gezina Anna Theresia Quality of life and depressive symptoms in patients with heart failure
2007 Liu, Yan Long-term consequences of neonatal glucocorticoid treatment
2007 Los, E.L. Intestinal function in cholestasis and essential fatty acid deficiency
2007 Luttikhuizen, Daniël Theodoor The dynamic niche of the foreign body reaction : messages and messengers for regenerative medicine
2007 Ma, Yue Classical Hodgkin lymphoma: investigation of the cross-talk between the HRS cells and the reactive lymphocytes
2007 Mare, Arjan de Immunotherapy based on influenza virosomes and recombinant Semliki Forest virus : novel strategies for the treatment of cervical cancer
2007 Mom, Constantijne Helene Exploring targeted therapies in oncology
2007 Mulder, Douwe Johannes Skin autofluorescence in cardiovascular disease : a non-invasive Approach for assessing inflammatory and oxidative stress
2007 Niens, Marijke Genetic factors involved in EBV-postitive and EBV-negative Hodgkin lymphoma susceptibility : role of HLA-A and chemokine polymorphisms
2007 Niessen, Renée Cecil Molecular aspects of HNPCC and identification of mutation carriers
2007 Nijhuis, Esther Raphael New prognostic and diagnostic options in cervical neoplasia
2007 Peels, Johannes Otto Jacobus Practical and strategic issues for off-site Percutaneous Coronary Intervention : clinical outcome within the Dutch healthcare system
2007 Rijn, Margaretha van Dietary Treatment in PKU from experience to evidence
2007 Rujano Maldonado, María Alexandra Protein quality control pathways in polyglutamine diseases
2007 Schepers, Hein Aberrant signal transduction and protein expression in acute myeloid leukemia
2007 Schot, Bartholomeus Wilhelmus Positron emission tomography in malignant haematological disease
2007 Signore, Alberto Radiolabelled interleukin 2 for in vivo imaging of activated T-lymphocytes
2007 Stellinga-Boelen, Annette Agnes Maria Nutritional assessment of asylumseekers' children in The Netherlands
2007 Sturm, Heidrun Beate Influencing physician prescribing in an international context : the role of systems, policies, and patients
2007 Trzpis, Monika The double face of EpCAM
2007 Veen, Jelske Nynke van der Nuclear receptors in control of cholesterol transport
2007 Verdonk, Robert Christiaan Complications after liver transplantation : a focus on bowel and bile ducts
2007 Visser, Annemieke Children's functioning following parental cancer
2007 Vries, Jessica de Developments in electrical neurostimulation for angina
2007 Wal, Marretje Hendrika Louise van der Compliance in heart failure patients: who cares?
2007 Smit, Jannetje Improving long-term outcome of major depression in primary care : the role of recurrence prevention
2007 Weersma, Rinse Karel Genetic susceptibility for inflammatory bowel diseases
2007 Eijkelkamp, Wouter Bernardus Alfons Reversing the reno-cardiac perspective
2006 Atthobari, Jarir Drug use in population screening. Pharmacoepidemiological and pharmacoeconomical aspects
2006 Beerens, Anthonius Martinus Johannus Intercellular spread of the transgene product to improve the efficiency of cancer gene therapy
2006 Boterman, Mark Heterologous amplification of homologous beta-adrenoceptor desensitization in airway smooth muscle : implications for asthma?
2006 Bovenkamp, Marja van den Liver fibrosis in vitro: Liver slices as a promising alternative
2006 Dickhoff, Bastiaan Hendrikus Jozef Adhesive mixtures for powder inhalation: The effect of carrier (surface and bulk) properties, carrier payload and mixing conditions on the performance of adhesive mixtures for inhalation
2006 Drooge, Dirk Jan van Combining the incompatible : inulin glass dispersions for fast dissolution, stabilization and formulation of lipophilic drugs
2006 Faber, Adrianne Stimulant treatment in children: A Dutch perspective
2006 Freije, Jan Robert Development of an integrated system for activity-based profiling of matrix metallo-proteases
2006 Gommans, Willemijn Maria Exogenous and endogenous gene regulation for specific and efficient cancer gene therapy
2006 Gonzalo Lázaro, Teresa A potential strategy to treat liver fibrosis: Drug targeting to hepatic stellate cells applying a novel linker technology
2006 Greupink, Albert Hendrikus The hepatic stellate cell in sight : targeting antiproliferative drugs to the fibrotic liver
2006 Hagens, Werner Ivo Arming drug carriers to disable the Hepatic Stellate Cell : the targeted delivery of apoptosis-inducing drugs to the fibrotic liver
2006 Jong , Jacob Jan Dirk de Dithienylcyclopentene optical switches : addressing dynamic chirality and aggregation
2006 Jong , Lutske Aafke Anna de Development and application of receptor assays for bioanalysis and toxicology : the dopamine D2S receptor, the mu-opioid receptor, and the benzodiazepine receptor
2006 Julsing, Mattijs Kamiel Bioconversion and combinatorial biosynthesis of selected terpenoids and lignans
2006 Klok, Rogier Martijn Pharmacoeconomic analysis of proton pump inhibitor therapy and interventions to control Helicobacter pylori infection
2006 Liu, Danyang Design, synthesis and pharmacological evaluation of Enone prodrugs : orally active precursors of catecholamines with antiparkinsonian activity
2006 Maarsingh, Harm Arginase: a novel key enzyme in the pathophysiology of allergic asthma
2006 Martignoni, Marcella Species and strain differences in drug metabolism in liver and intestine
2006 Meijer, Willemijn Marieke Drug safety in pregnancy : studying and communicating teratogenic risks
2006 Oldenziel, Weite Hendrik Application of a glutamate microsensor to brain tissue
2006 Prakash, Jai Renal-specific delivery of antifibrotic drugs using lysozyme: a novel approach for the treatment of renal fibrosis
2006 Rea, Kieran Augmentation of the neurochemical and behavioural effects of SSRIs
2006 Rieux, Laurent A nanoLC-MS-based platform for peptide analysis
2006 Sloot, Albert Martinus Design and engineering of human TRAIL variants
2006 Adrian, Joanna Ewa Addressing liver fibrosis with lipid-based drug carriers targeted to hepatic stellate cells
2006 Amerongen, Machteld Jacomien van Wound healing after myocardial infarction : new ways to mend a broken heart
2006 Atayar ÇiÄŸdem Dysregulation of transcription and cytokine networks in Hodgkin lymphomas with a focus on nodular lymphocyte predominance type of Hodgkin lymphoma
2006 Bakker-van Waarde, Willemijntje Maria Bile salt and cholesterol metabolism in diabetes mellitus type 1
2006 Bergstra, Arend Implementation of new and conventional techniques in the measurement of haemodynamics in the catheterisation laboratory
2006 Boomker, Jasper Martijn Versatile actions of viral chemokine modulators in inflammation and infection : experimental studies on M-T7 and US28
2006 Bosga-Bouwer, Annigje Geesje Follicular Lymphoma grade 3B. A separate entity?
2006 Bremer, Edwin Targeted induction of apoptosis for cancer therapy
2006 Breukink, Stéphanie Olga Laparoscopic total mesorectal excision for rectal cancer
2006 Burzynski, Grzegorz Maciej Hirschsprung disease - genetics and development
2006 Buursma, Anne Rixt Monitoring transgene expression with positron emission tomography : a preclinical evaluation
2006 Cavagis, Alexandre Donizeti Martins Mechanisms of drug-induced apoptosis in human leukemia
2006 Conde de la Rosa, Laura Mechanisms of oxidative stress-induced cell death in hepatocytes: targets for protective intervention
2006 Cromheecke, Michel Tissue tolerance of the canine liver to intraoperative radiotherapy : an experimental study
2006 Dijkhuis, Anne-Jan Sphingolipids, ABC transporters and chemosensitivity in neuroblastoma
2006 Diks, Sander H. Analysis of protein superhighways in cell biology
2006 Dobbeleir, André Alfons Quantification and data optimisation of heart and brain studies in conventional nuclear medicine
2006 Elst, Arja ter On the elucidation of a tumour suppressor role of 3p in lung cancer
2006 Fleer, Joke Quality of Life of Testicular Cancer Survivors
2006 Geuken, Wirtje Molecular changes in hepatobiliary function and injury after human liver transplantation
2006 Gosman, Margot Madeleine Elvira From pathology to treatment in chronic obstructive pulmonary disease : focus on inflammatory cells and airway hyperresponsiveness
2006 Grefhorst, Aldo Insulin sensitivity of hepatic glucose and lipid metabolism in animal models of hepatic steatosis
2006 Groot, Derk Jan Alko de The apoptosis pathway: a drugable target in solid tumors
2006 Groot, Johannes Willem Berend de Medullary thyroid cancer
2006 Hafkamp, Anja Maria Oral treatment of unconjugated hyperbilirubinemia
2006 Harst, Pim van der Lipids, inflammation, and the Renin-Angiotensin System
2006 He, Tao Lactose intolerance: the role of colonic metabolism
2006 Hogenhuis, Jochem BNP and NT-proBNP in heart failure : benefits and limitations for clinical ractice : data from COACH and other studies
2006 Hougardy, Brigitte Manon Thérèse Modulation of death receptor-mediated apoptosis in cervical neoplasia
2006 Huizinga, Geertje Anke The impact of parental cancer on children
2006 Jalving, Mathilde Apoptosis pathways in (pre)malignant gastrointestinal tumours: potentials for intervention
2006 Jongsma, Minke Elizabeth Serotonergic augmentation strategies; possibilities and limitations
2006 Khan, Muhammad Mushtaq Health policy analysis: the case of Pakistan
2006 Kluiver, Joost Laurens Gene expression in Hodgkin lymphoma. The role of miR-155 in normal and malignant B cells
2006 Koornstra, Jan Jacob Apoptosis and colorectal cancer. Studies on pathogenesis and potential therapeutic targets
2006 Kramer, Andrea Brechtsje Proteinuria-associated renal injury and the effects of intervention in the renin-angiotensin-aldosterone system
2006 Kruit, Janine Krista Emerging roles of the intestine in reverse cholestorol transport
2006 Kusumanto, Yoka Hadiani Vascular Endothelial Growth Factor, diagnostic and therapeutic aspects
2006 Lefrandt, Johan Daniël Autonomic dysfunction in cardiovascular disease
2006 Lipsic, Erik Erythropoietin in cardiac ischemia
2006 Lub-de Hooge, Marjolijn Nicolette New receptor targeted drugs: pharmaceutical aspects and molecular imaging
2006 Luttik, Maria Louise Agatha Patients with heart failure and their partners both sides of the picture. Benefits for patient outcome and impact on the partner’s life
2006 Ochodnicky, Peter Vascular endothelial and myogenic function in renal disease: Focus on individual susceptibility to organ damage
2006 Oostenbrug, Liekle Eelco Low penetrance susceptibility genes in inflammatory bowel disease
2006 Pasmooij, Anna Maria Gerdina Genotyping of unusual phenotypes of epidermolysis bullosa
2006 Pijpe, Justin Diagnosis, progression and intervention in Sjogren's syndrome
2006 Plaza-Menacho, Ivan Functional analysis of RET in MEN2
2006 Reefman, Esther Apoptotic cell clearance in Systemic Lupus Erythematosus (SLE)
2006 Rijcken , Fleur Elise Marie Heredity nonpolyposis colorectal cancer : studies on tumor development and preventive strategies
2006 Rust, Renata Three childhood malignancies with striking morphologic and phenotypic similarities : how about gene expression?
2006 Sandovici, Maria Gene therapy in kidney transplantation : towards local immune suppression
2006 Theard, Delphine Francine p27Kip1 in cell-cell adhesion and cell polarity
2006 Thijssens, Katja Maria Jozef Soft tissue sarcomas: long-term aspects of combined modality treatment
2006 Vaart, Hester van der COPD, from first cigarette to therapy
2006 Velde, Susanne van der Stem cell-mediated regeneration of the infarcted heart : inflammation rules?
2006 Verschuuren, Erik Alfons Maria Balance between herpes viruses and immunosuppression after lung transplantation
2006 Vries, Hilda Ineke de Grapes- and stonewall-related DNA damage responses in Drosophila melanogaster
2006 Vries, Harry de Midgut carcinoids; surgical aspects, biogenic amines and vascular effects
2005 Bouwman, Anneke Margriet Form, formation, and deformation : the influence of material properties and process conditions on the shape of granules produced by high shear granulation
2005 Jong, Johannes Rinse de Conformational properties of comb copolymer brushes: Persistence and Curvature
2005 Jong, Jelte Teun Anne de Microlensing in Andromeda
2005 Rachmawati, Heni The design of a liver-selective form of interleukin-10 : a new strategy for
2005 Asselbergs, Folkert Wouter Vascular function and cardiovascular disease : risk stratification and early pharmacological intervention
2005 Bartsch, Martin Targeted in vivo delivery of nucleic acids by lipid-based carriers
2005 Bos, Elisabeth Henriëtte Interpersonal mechanisms in recurrence of depression
2005 Eisses, Anne-Marie Henriëtte Depressie bij verzorgingshuisbewoners
2005 Fuhler, Gwenny Manel Neutrophil functions in patients with myelodysplasia : implications of impaired
2005 Geelen, Caroline Mirjam Maria van TRAIL-induced apoptosis in colon cancer : resistance and modulation
2005 Hoeven, Joost Alexander Boreas van der Effects of brain death on donor organ viability in transplantation
2005 Hut, Henderika Magrietha Janet Centrosomes and cellular stress responses
2005 Jong, Mirjam Miranda de Identification of genes other than the high-penetrance genes involved in colorectal and/or breast cancer susceptibility
2005 Kamminga, Leonie Marjan Hematopoietic stem cells and the genetics of aging
2005 Kocks, Menno Johan Adelbert Sodium intake and therapy resistance to ACE inhibition : renal and vascular mechanisms
2005 Kosterink, Johannes Gerardus Wilhelmus Strategies for specific drug targeting to tumor cells : radiolabeled monoclonal
2005 Langeveld, Bartholomeus Experimental in-stent restenosis in rats : the importance of systemic endothelial function
2005 Loot, Annemarieke Elisabeth Therapeutic perspectives of Angiotensin-(1-7) in heart failure
2005 Maring, Jan Gerard New insights in pyrimidine antagonist chemotherapy : the role of pharmacokinetics and pharmacogenetics
2005 Maring, Jan Kornelis Studies on predictability of early graft function after liver transplantation
2005 Meer, Peter van der Anemia and erythropoietin in heart failure
2005 Mol, Petrus Gerardus Maria The quest for optimal antimicrobial therapy
2005 Nuver, Janine Chemotherapy-related vascular toxicity : studies in germ cell tumour patients
2005 Oostendorp, Jaap Beta-adrenergic receptor regulation and airway inflammation
2005 Perik, Patrick Jozef Cardiotoxicity after anticancer treatment: clinical investigations and molecular mechanisms
2005 Plass, Jacqueline Regina Maria Function and regulation of the human bile salt export pump
2005 Plasschaert, Sabine Louise Anne The role of ABC-transporters in childhood and adult acute lymphoblastic leukemia
2005 Qu, Ning Airway epithelium in obliterative airway disease
2005 Rossum, Aart Pieter van Activation, apoptosis and clearance of neutrophils in Wegener's granulomatosis
2005 Schaapveld, Michael Breast cancer: patterns of care, second cancers and genetics : studies based on cancer registry data
2005 Smilde, Tom Derk Jan Left ventricular and renal dysfunction : an exploration of the cardiorenal axis
2005 Stokman, Monique Astrid New options for evaluation and intervention of cancer therapy induced oral mucositis
2005 Kramer, Hendrikus Endoscopic ultrasound and PET in the staging of lung cancer
2004 Bos, Jasper Marnix Pharmacoeconomics in infectious disease: the evaluation of prevention programmes.
2004 Dorenbos, Ronald Thiol-disulfide oxidoreductases in Bacillus subtilis
2004 Eriksson, Hans Jonas Christian Analytical techniques and formulation strategies for the therapeutic protein alkaline phosphatase
2004 Gosens, Reinoud Plasticity of airway smooth muscle phenotype in airway remodeling
2004 Jong, René Marcel de Molecular basis of two novel dehalogenating activities in bacteria : structure/function relationships in an evolutionary context
2004 Otten, Ludwina Gerharda Directed evolution of a cephalosporin acylase : changing the substrate specificity of the industrially relevant glutaryl acylase from Pseudomonas SY-77
2004 Sio, Charles Frederik Mutants and homologs of cephalosporin acylase : for antibiotics and antibiosis
2004 Bandsma, Robertus Hermanus Johannes Interactions between carbohydrate and lipid metabolism in metabolic disorders
2004 Bungener, Laura Barbara Therapeutic immunization strategies against cervical cancer : induction of cell-mediated immunity in murine models
2004 Cobben, David Catharina Petrus Detection and staging of solid tumors with FDG-PET and FLT-PET
2004 Dijkstra, Gerard Inducible nitric oxide synthase in intestinal inflammation
2004 Groot, Martijn de Immunoprotection of pancreatic islets : in vitro studies into causes of microencapsulated graft failure
2004 Heijink, Hilde Irene Dysregulation of T cell activity in asthma : role of the ß2-adrenergic/cAMP system
2004 Hendriks, Herman George Dirk Transfusion requirements in orthotopic liver transplantation
2004 Hinrichs, Joann Wilhelm Jakob Sphingolipids, rafts and multidrug resistance
2004 Hulzebos, Christian Victor The enterohepatic circulation of bile salts in health and disease : a kinetic approach
2004 Kasje, Willeke Nynke Implementing joint treatment guidelines to improve prescribing in general practice
2004 Khan, Mohammad Enayet Hossain Typhoid fever in a South African in-patient population
2004 Kok, Tineke Regulation of hepatobiliary transport function by nuclear receptors
2004 Luik, Pieter Teunis The ACE (I/D) polymorphism and the RAAS in type 1 diabetes mellitus
2004 Plösch, Torsten The ABC of cholesterol transport
2004 Posthumus, Marcel Desiderius The significance of serum matrix metalloproteinase 3 in patients with early rheumatoid arthritis
2004 Schoemaker, Marieke Henriëtte Apoptotic cell death as a target for the treatment of acute and chronic liver injury
2004 Shi, Fuxin On the mechanism of cationic lipid-mediated delivery of oligonucleotides : towards an antisense therapy
2004 Stuveling, Erik Marcel C-reactive protein and albuminuria : independent risk markers of renal and cardiovascular disease
2004 Verbeek, Henrica Maria Johanna Cornelia Insomnia in perspective : diagnosis, treatment and education
2004 Verhave, Jacoba Catharijne The impact of albuminuria and cardiovascular risk factors on renal function
2004 Vonk, Judith Marijke Development and outcome of asthma.
2004 Waarts, Barry-Lee Cell entry mechanisms of alphaviruses : receptor interaction and membrane fusion in a liposomal model system
2004 Dillen, Ingrid Johanna van Preclinical evaluation and visualization of herpes simplex virus thymidine kinase/ganciclovir suicide gene therapy
2004 Jongepier, Hajo Polymorphisms in genes contributing to asthma, its severity and progression.
2004 Guikema, Jeroen Elze Jan Heterogeneity of clonal B cells in Multiple Myeloma
2004 Pudovkina, Olga Leonidovna Noradrenergic neurons of the rat locus coeruleus studied by microdialysis
2003 Koulman, Albert Podophyllotoxin : a study of the biosynthesis, evolution, function and use of podophyllotoxin and related lignans
2003 Rijcken, Claudia Anna Wilhelmina Pharmacy data as a tool for assessing antipsychotic drug use : the pharmacists' challenge in schizophrenia care
2003 Schirm, Eric Drug exposure from conception till adulthood
2003 Albrecht, Ester Willemina Johanna Annetje The role of nitric oxide in renal transplant failure
2003 Berge, Maarten van den AMP and its role in asthma
2003 Boonstra, Ronald Application of comparative genomic hybridization to identify genetic regions of relevance to tumor development or progression
2003 Bos, Anna Margaretha Elisabeth Optimizing conventional echemotherapy approaches. Studies on feasibiblity and pharmacokinetics.
2003 Elzinga, Baukje Marije Effects of bile salts on hepatic lipoprotein production
2003 Hoekstra, Pieter Jan Is Gilles de la Tourette's syndrome an autoimmune disease?
2003 Komdeur, Rudy Resistance and perspectives in soft tissue sarcomas
2003 Maar, Eltjo Fredericus de Changing images of cytomegalovirus infection
2003 Rarok, Agnieszka Anna Interactions of antineutrophil cytoplasm autoantibodies with neutrophil proteinase 3 in systemic vasculitis
2003 Slebos, Dirk-Jan Pathopysiology and airway inflammation in bronchiolitis obliterans after lung transplantation.
2003 Veen, Bert van Compaction of powder blends : effect of pores, particles and percolation on tablet strength
2003 Fokkema, Margaretha Rebecca Functional markers for the assessment of (sub)clinical micronutrient deficiencies. Contributions to the diagnosis of hyperhomocysteinemia and essential fatty acid deficiency.
2003 Bart, Joost Function and expression of p-glycoprotein in blood-tissue barriers; translational studies
2003 Kerkhof, Marjan Allergic diseases in the general population
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