Advanced Drug Delivery & Drug Targeting
A joint effort between the Leiden Amsterdam Center for Drug Research (LACDR), the Groningen University Institute of Drug Exploration (GUIDE), and the Utrecht Institute for Pharmaceutical Sciences (UIPS)
In recent years, new chemical and biotechnological entities have been developed and several of these compounds already entered the stage of preclinical and clinical development. In the development of new products one of the main scientific challenges is to deliver the drug in a controlled way at the desired site of action.
In the Advanced Drug Delivery / Drug Targeting course, experts in the field of
- Drug formulation and delivery via various routes of administration
- Targeting drugs to the site of action
- The use of cell culture systems in the design of novel drug delivery systems
- Vaccine and protein delivery by the parenteral, mucosal and dermal route
- Translation of a concept to a product
will provide an in depth overview of the newest strategies and achievements in the drug delivery and targeting field. Particular emphasis will be put on the delivery of macromolecules, including vaccines, proteins and genetic material. In addition, the use of cell culture systems in the development of drug delivery systems will be thoroughly discussed. The participants will actively work in groups on assignments in which they will address various issues relevant to the development of therapeutic strategies employing drug delivery and drug targeting technologies. Online computer facilities are available throughout the course for the assignments and for preparing of the oral presentations that accompany the assignments.
Tentative course programme November 2008
Monday November 24
Delivery routes and delivery systems
10.00 Opening
10.15 Pulmonary and nasal delivery: Prof.Dr. Erik Frijlink
11.15 Dermal/transdermal delivery: Prof.Dr. Joke Bouwstra
12.15 Lunch
13.15 Oral delivery: Prof.Dr. Clive Wilson
14.15 Coffee break
14.45-17.45 hours: Start of group assignments: introduction
19.00 Dinner
Tuesday November 25
Delivery and targeting issues
9.00 Hydrogels for drug delivery: Prof.Dr. Wim Hennink
10.00 Coffee break
10.30 Injection + liposomes: Prof.Dr. Gert Storm
11.30 Endothelial targeting: Prof.Dr. Ingrid Molema
12.30 Lunch
13.30 Intracellular delivery of siRNA: Dr. Raymond Schiffelers
14.30 Coffee break
15.00 Overcoming the blood-brain barrier: Dr. Bert de Boer
16.00-17.45 Assignments
Wednesday November 26
The use of cell culture systems in drug delivery and targeting
9.00 Dendritic cells: Dr. Elly van Riet
10.00 Coffee break
10.30 Nasal: Prof.Dr. Patrick Augustijns
11.30 Skin: Dr. Abdoel El Ghalbzouri
12.30 Lunch
13.30 Oral: Prof.Dr. Veronique Préat
14.30 Coffee break
13.00-17.45 Assignments
Thursday November 27
Delivery of vaccines and proteins
9.00 Protein formulation: Dr. Marc Sutter
10.00 Coffee break
10.30 Vaccine delivery: Prof.Dr. Wim Jiskoot
11.15 Mucosal Vaccination: Prof.Dr. Wim Jiskoot
11.45 Dermal Vaccination: Prof.Dr. Joke Bouwstra
12.15 Lunch
13.15-17.45 Assignments
Friday November 28
Translation from concept to product
9.00 How to start a company: Dr. Pieter Gaillard
10.00 Coffee break
10.30 From invention to product development: controlled release protein formulation:
Dr. Leo de Leede
11.30 Drug delivery and prospects: Prof.Dr. Herman Vromans
12.30 Lunch
13.30-17.00 Assignments: oral presentations
Who should attend
Researchers (researchers in training, postdoctoral fellows, research associates, research project managers) in Universities, Pharmaceutical Industry, Biotechnology Industry, and Federal Research Laboratories, whose research or research interests lie in the area of new technologies facilitating drug distribution, delivery, release, and effectiveness.
Credits: The course is KNMP accredited for 3 credit points, and by EUFEPS and the GALENOS Network.
Date:
Place:
Information/registration:
Costs*
GUIDE/UIPS/LACDR PhD students: € 425
PhD-students and postdocs from other universities, university affiliates: € 575
Non-academic affiliates: € 1,450
* includes course materials and lunches. Travel costs, housing and dinner are excluded.
